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Pub date
2010-01-31
Osteoporosis in the elderly need to take drugs and reasonable
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Osteoporosis in the elderly need to take drugs and reasonable
Osteoporosis lies in prevention, the event of osteoporosis, in the emphasis on exercise, better nutrition conditioning, to develop good habits should be accompanied by the necessary medical treatment to reduce bone loss and prevent symptoms of the deteriorated. Osteoporosis is a serious impact on people's quality of life of a common disease, to the elderly in particular in women than men. Osteoporosis lies in prevention, the event of osteoporosis, in the emphasis on exercise, better nutrition conditioning, to develop good habits should be accompanied by the necessary medical treatment to reduce bone loss and prevent symptoms of the deteriorated. Commonly used drugs are mainly the following categories:
Calcium: increased calcium intake, a negative calcium balance can become positive calcium balance, beneficial to bone remodeling, and bone calcium balance was increased, can reduce the incidence of fractures. The elderly daily dietary supply of calcium to be at least 800 milligrams, but the elderly in general are relatively poor intestinal absorption, inadequate dietary intake, mostly, so best to add extra calcium, and the older, add calcium should be more people over the age of 65, daily calcium supplement should be 1500-2500 mg. For women, calcium is particularly important, from the cessation of growth and development to 35-year-old at this stage, the general should be a daily intake of 800-1000 mg of calcium, pre-and post-menopausal women, daily calcium intake can not be less than 1000 mg, If you do not take estrogen, daily calcium intake should be increased to 1500 mg, to ensure adequate calcium, dietary intake alone obviously does not work, had to add extra. However, calcium kidney stone patients or high risk of kidney stones occur in patients with calcium should be careful.
Vitamin D and the activity of products: the absorption of calcium needs vitamin D, in combination, balancing the use, can reduce serum parathyroid hormone secretion, so that inhalation of blood back to the amount of bone calcium significantly reduced, increased bone calcium. Osteoporosis are often vitamin D-resistant, so dosage should be increased to 4,000 international units a day. At present, more commonly used is the logai more than 0.5mg a day to give the most effective, but also the safest.
Sex hormones: sex hormones in the human body can promote bone protein synthesis, stimulate bone cell growth and maintenance of bones strong and sturdy. May be appropriate to add some sex hormones are conducive to the fight against osteoporosis. Men can add long-acting testosterone preparations, can enhance bone cell activity, inhibit bone resorption, so that bone mineral density increased. Post-menopausal women, especially women, should be supplemented with estrogen, because estrogen can reduce bone tissue of the sensitivity of parathyroid glands to stimulate the rejection of bone cells to produce bone matrix, inhibit bone resorption, correct the negative calcium balance, while also making Ca and urinary hydroxyproline reduced the prevention of bone calcium back to the effect of inhalation of blood. However, the use of sex hormones should be carried out under the guidance of doctors, pharmaceutical dosage, length of treatment and withdrawal should be determined according to specific circumstances, and also to pay close attention to the reaction after use, especially the availability of liver damage and endometrial proliferation and functional bleeding situation. Atherosclerosis by medication should be careful.
Calcitonin: calcitonin inhibit osteoclast activity, reducing the number of osteoclasts, reduce the role of bone turnover. In addition, there is analgesic effect of calcitonin. But it should be used in conjunction with calcium preparations in order to overcome the excessive calcitonin reduces blood calcium and increased bone recovery. Occasionally occur during use, nausea, vomiting and other side effects. Their effective short time, usually in 12-16 months, the prolonged use of drug resistance will appear.
NaF: sodium fluoride can stimulate bone formation and increase trabecular bone mass. General day to take 50-80 mg, while calcium may be medication for six months, stopping for six months alternately. However, the side effects of sodium fluoride are more used doses should not be too large, and should be under the guidance of a doctor's medication.
Double Phosphates: Double-phosphate can reduce bone resorption, inhibit osteoclast activity, can increase the bone mass of loose body. Now commonly used in bone phosphorus, Japanese oral 400 mg, 3 months for a course of treatment. If the condition is more serious may be the first to use injections, intravenous drip, continuous infusion of 3-5 days, but not more than 7 days, otherwise it would cause hypocalcemia.
Osteoporosis lies in prevention, the event of osteoporosis, in the emphasis on exercise, better nutrition conditioning, to develop good habits should be accompanied by the necessary medical treatment to reduce bone loss and prevent symptoms of the deteriorated. Osteoporosis is a serious impact on people's quality of life of a common disease, to the elderly in particular in women than men. Osteoporosis lies in prevention, the event of osteoporosis, in the emphasis on exercise, better nutrition conditioning, to develop good habits should be accompanied by the necessary medical treatment to reduce bone loss and prevent symptoms of the deteriorated. Commonly used drugs are mainly the following categories:
Calcium: increased calcium intake, a negative calcium balance can become positive calcium balance, beneficial to bone remodeling, and bone calcium balance was increased, can reduce the incidence of fractures. The elderly daily dietary supply of calcium to be at least 800 milligrams, but the elderly in general are relatively poor intestinal absorption, inadequate dietary intake, mostly, so best to add extra calcium, and the older, add calcium should be more people over the age of 65, daily calcium supplement should be 1500-2500 mg. For women, calcium is particularly important, from the cessation of growth and development to 35-year-old at this stage, the general should be a daily intake of 800-1000 mg of calcium, pre-and post-menopausal women, daily calcium intake can not be less than 1000 mg, If you do not take estrogen, daily calcium intake should be increased to 1500 mg, to ensure adequate calcium, dietary intake alone obviously does not work, had to add extra. However, calcium kidney stone patients or high risk of kidney stones occur in patients with calcium should be careful.
Vitamin D and the activity of products: the absorption of calcium needs vitamin D, in combination, balancing the use, can reduce serum parathyroid hormone secretion, so that inhalation of blood back to the amount of bone calcium significantly reduced, increased bone calcium. Osteoporosis are often vitamin D-resistant, so dosage should be increased to 4,000 international units a day. At present, more commonly used is the logai more than 0.5mg a day to give the most effective, but also the safest.
Sex hormones: sex hormones in the human body can promote bone protein synthesis, stimulate bone cell growth and maintenance of bones strong and sturdy. May be appropriate to add some sex hormones are conducive to the fight against osteoporosis. Men can add long-acting testosterone preparations, can enhance bone cell activity, inhibit bone resorption, so that bone mineral density increased. Post-menopausal women, especially women, should be supplemented with estrogen, because estrogen can reduce bone tissue of the sensitivity of parathyroid glands to stimulate the rejection of bone cells to produce bone matrix, inhibit bone resorption, correct the negative calcium balance, while also making Ca and urinary hydroxyproline reduced the prevention of bone calcium back to the effect of inhalation of blood. However, the use of sex hormones should be carried out under the guidance of doctors, pharmaceutical dosage, length of treatment and withdrawal should be determined according to specific circumstances, and also to pay close attention to the reaction after use, especially the availability of liver damage and endometrial proliferation and functional bleeding situation. Atherosclerosis by medication should be careful.
Calcitonin: calcitonin inhibit osteoclast activity, reducing the number of osteoclasts, reduce the role of bone turnover. In addition, there is analgesic effect of calcitonin. But it should be used in conjunction with calcium preparations in order to overcome the excessive calcitonin reduces blood calcium and increased bone recovery. Occasionally occur during use, nausea, vomiting and other side effects. Their effective short time, usually in 12-16 months, the prolonged use of drug resistance will appear.
NaF: sodium fluoride can stimulate bone formation and increase trabecular bone mass. General day to take 50-80 mg, while calcium may be medication for six months, stopping for six months alternately. However, the side effects of sodium fluoride are more used doses should not be too large, and should be under the guidance of a doctor's medication.
Double Phosphates: Double-phosphate can reduce bone resorption, inhibit osteoclast activity, can increase the bone mass of loose body. Now commonly used in bone phosphorus, Japanese oral 400 mg, 3 months for a course of treatment. If the condition is more serious may be the first to use injections, intravenous drip, continuous infusion of 3-5 days, but not more than 7 days, otherwise it would cause hypocalcemia.
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