Conventional laboratory: the onset of platelets can be found in the course of individual reports of increased platelet up to 1000 × 109 / L serum CEA increased in some patients immune serum IgM electrophoresis phenomenon IgGIgA or not the reasons for increased serum-fetoprotein general Normal
 
Exudative pleural effusion are particularly exposed to asbestos have a history of the patient should be considered malignant pleural stromal tumor of the skin of the chest CT can confirm the diagnosis chest CT scan can determine if the pleural calcification or bone structure damage when the tumor has violated the diaphragm and chest wall at the MRI The imaging is better than CT (Figure 1) Although the pleural effusion cells smear wear pleural biopsy and chest pleural effusion cell block section can make the diagnosis of malignant pleural but we can not identify metastatic carcinoma and malignant skin Liu

　　 　　

Figure 1 magnetic resonance: the right lower chest wall malignant pleural mesothelioma

Under the lower left lung Yebei layer of dirt has malignant pleural mesothelioma (surgery confirmed)

In the past 10 years has developed three kinds of technology relatively sure will help make the diagnosis of malignant mesothelioma these three kinds of technology are periodate - Schiff staining of doing to keratinocytes and carcinoembryonic antigen for immune-off Oxides of testing and electron microscope examination for the conduct of these inspections biopsy specimens must be immediately used in the Lok Ma Lin Xingfu of fixed another small tumor biopsy specimens destined for the glutaraldehyde solution for the use of electron microscopy

Periodate - Schiff stain (PAS) is the only reliable technique can distinguish between malignant pleural mesothelioma and cancer Although various metastatic adenocarcinoma of the same characteristics but not in the digestion of starch after the strong positive cavity that is Can be diagnosed with cancer rather than malignant pleural mesothelioma

Immune peroxidase antibody technology is used in the angle of prion protein and cancer antigen (CEA) of this Act also effectively distinguish between malignant pleural mesothelioma in metastatic adenocarcinoma of the carcinoembryonic antigen for immune peroxidase stain of malignant pleural Staining of the skin is very short general coloring may stain the contrary adenocarcinoma of the middle and very strong immune peroxidase In addition to the keratinocytes study also showed that mesothelioma and cancer are significant differences have been found eight marks for identification Used: tumor merger glycoprotein 72 (B72.3), Leu-Mi, Vimentin mucin-thrombosis Treating cancer antigen positive elements of cancer are 100 percent because of the sensitivity and specificity of carcinoembryonic antigen test is most often false negative Good selection of a general use of tumor markers CEA and B72.3 if there were a hundred percent of adenocarcinoma of the specificities and 88 percent of the sensitivity of mesothelioma as both a negative 100% of the specificities and 97 % Of the sensitivity of

Electron microscope examination of the identification of malignant pleural mesothelioma and pleural metastatic adenocarcinoma also use different from malignant pleural mesothelioma lung and breast cancer, gastrointestinal cancer is the source of its surface microvilli small branch of a long and tension wire No more rich microvilli of small roots and film equipment; from ovarian and endometrial metastatic adenocarcinoma of the inherent deformation organizations including the rich mucin large number of cilia-intensive small trickle of nuclear particles of these changes in stromal tumor is not Adenocarcinoma of the villi short and thick