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 Pub date
2008-09-15

Peritoneal mesothelioma surgery and radiotherapy

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Peritoneal mesothelioma (peritoneal mesothelioma) in the primary peritoneal mesothelial organizations and epithelial tumors, clinical rarely see. Pathology, may be divided into adenomatous mesothelioma (adenomatoid mesothelioma), cystic mesothelioma (cystic mesothelioma) and malignant mesothelioma (peritoneal malignant mesothelioma, PMM). Peritoneal mesothelioma (peritoneal mesothelioma) in the primary peritoneal mesothelial organizations and epithelial tumors, clinical rarely see. Pathology, may be divided into adenomatous mesothelioma (adenomatoid mesothelioma), cystic mesothelioma (cystic mesothelioma) and malignant mesothelioma (peritoneal malignant mesothelioma, PMM). The first two are benign. Cystic mesothelioma more common in women, cause unknown, occurred in the surrounding pelvic or annex, a single or multiple cystic mass; patients often palpable abdominal mass and treatment. Malignant peritoneal mesothelioma (PMM) malignant mesothelioma about 30 percent of its occurrence and also closely related to exposure to asbestos, about 5 percent of patients have a history of exposure; asbestos fiber intake by mouth, through the intestinal wall to the translocation Peritoneal and pleural disease or from the transfer from. From exposure to asbestos-diagnosed, the disease incubation period of up to 25 to 40 years. However, domestic 1951 to 1993 20 PMM literature reports 161 cases, only one case of a history of exposure to asbestos. Zhou Ya Kang, and other reports of 47 cases of mesothelioma in eight cases of malignant peritoneal mesothelioma, and I gather the two cases have a history of exposure to asbestos. No history of exposure to asbestos in the crowd, the incidence rate of about 1 / 1 million years, and some may be infected with the virus and genetic factors. Foreign PMM reported one case of patients over 40 years ago, glial contact with thorium dioxide (Thorotrast). PMM often occurred in more than 40-year-old male. Dirty floor or layer can Li and peritoneal tumor can be a direct violation of abdominal, pelvic organ; 50 percent to 70 percent of patients with lymph node and / or blood transfer of liver, kidney and adrenal gland, lung, bone, and so on.

Malignant mesothelioma

1 surgical therapy:

For I, Ⅱ period PMM preferred treatment. Including by type of tumor surgery (cytoreductive surgery), as far as possible to see the removal of tumors. But the fact is difficult because of surgery, diffuse lesions, and difficult to attain the objective of complete resection. The recurrence can be re-operation. Possible obstruction to the palliative operation, ease the symptoms of obstruction.

2 radiotherapy:

PMM less sensitive to radiation therapy, radiation effect as pleural mesothelioma. But the operation has not been fully removed lesions or not surgery, radiotherapy is still an important therapy. Methods include irradiation, and (or) irradiation. Selection of the 60 Co irradiation general or 186 KV X line as the radioactive sources, depending on choice of the entire abdominal lesions or partial irradiation. Cancer Hospital on medical patients to the whole abdominal irradiation, six to seven weeks of radiation dose of 24 Gy, the results of local recurrence rate fell to 11.4 percent, three-year survival rate increased to 66.7 percent. Radiation can cause radioactive enteritis, radiation and radioactive myelitis, such as hepatitis. Intraperitoneal injection of radionuclide such as 32 P or 198 Au, through the radiation, so that mesothelioma organizations and small vessels sclerosis, and destruction of the free ascites tumor cells so that the illness was short-term mitigation. However, this method takes a certain equipment, and costly, and can inhibit the bone marrow, is now using less.

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